Florence Mongin

Head of CORINT - UR1 Professor

Florence Mongin

Email : florence [dot] mongin [at] univ-rennes1 [dot] fr

Phone : +33 (0) 2 23 23 69 31

Office number : Beaulieu 10A, Office 018

Research themes

Bimetallic bases
• Synthesis of molecules of biological interest

Scientific skills

• Aromatic heterocycles
• Copper catalysis
• Stereoselective syntheses of ferrocene derivatives
• Substituent effects

Education and professional experience

• Professor (2005-), Université de Rennes 1, Institut des Sciences Chimiques de Rennes, UMR 6226 (France)
• Junior member of the Institut Universitaire de France (2009-2014)
• D. Sc. in Chemistry (Habilitation à Diriger des Recherches, 2003), Université de Rouen (France)
• Assistant-professor (1997-2004), Université de Rouen, Institut de Recherche en Chimie Organique Fine, UMR CNRS 6014 (France)
• Post-doctoral fellow (1995-1997), Institute of organic Chemistry, University of Lausanne (Switzerland)
• PhD (1991-1994), Université de Rouen (France)

Main present international collaborations

• Ghenia Bentabed-Ababsa, Oran (Algeria)
• Ziad Fajloun, Tripoli (Lebanon)
• Yury Halauko, Minsk (Byelorussia)
• Palakodety Radha Krishna, Hyderabad (India)
• Masanobu Uchiyama and Yu Kitazawa, RIKEN, University Tokyo & Nagano (Japan)

Scientific Production


Florence Mongin studied Chemistry at the Université de Rouen where she obtained her PhD in 1994 under the supervision of Prof. Guy Quéguiner. After a two-year postdoctoral position at the Institute of Organic Chemistry of Lausanne with Prof. Manfred Schlosser, she returned to the University of Rouen as an Assistant Professor in 1997 (habilitation in 2003). She took up her present position in 2005 as Professor at the University of Rennes, and has been appointed Junior member of the Institut Universitaire de France from 2009 to 2014.

She is skilled in the functionalization of aromatic compounds including heterocycles, and in particular by using lithium bases or bimetallic complexes and combinations. Her present scientific interests also include the implementation of aromatic heterocycles to reach molecules of biological interest and the functionalization of ferrocenes.

Selected Publications

1. Copper- and cobalt-catalyzed syntheses of thiophene-based tertiary amines.
Bouarfa, S.; Graβl, S.; Ivanova, M.; Langlais, T.; Bentabed-Ababsa, G.; Lassagne, F.; Erb, W.; Roisnel, T.; Dorcet, V.; Knochel, P.; Mongin, F. Eur. J. Org. Chem. 2019, 3244-3258.
2. 2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities.
Mokhtari Brikci-Nigassa, N.; Bentabed-Ababsa, G.; Erb, W.; Chevallier, F.; Picot, L.; Vitek, L.; Fleury, A.; Thiéry, V.; Souab, M.; Robert, T.; Ruchaud, S.; Bach, S.; Roisnel, T.; Mongin, F. Tetrahedron 2018, 74, 1785-1801.
3. Deprotonative metalation of methoxy-substituted arenes using lithium 2,2,6,6-tetramethylpiperidide: experimental and computational study.
Akimoto, G.; Otsuka, M.; Takita, R.; Uchiyama, M.; Hedidi, M.; Bentabed-Ababsa, G.; Lassagne, F.; Erb, W.; Mongin, F. J. Org. Chem. 2018, 83, 13498-13506.
4. Fused systems based on 2-aminopyrimidines: synthesis combining deprotolithiation-in situ zincation with N-arylation reactions and biological properties.
Hedidi, M.; Maillard, J.; Erb, W.; Lassagne, F.; Halauko, Y. S.; Ivashkevich, O. A.; Matulis, V. E.; Roisnel, T.; Dorcet, V.; Hamzé, M.; Fajloun, Z.; Baratte, B.; Ruchaud, S.; Bach, S.; Bentabed-Ababsa, G.; Mongin, F. Eur. J. Org. Chem. 2017, 5903-5915 (Very Important Paper).
5. Synthesis of heterobiaryls featuring 1,4 N···S inter-ring interactions.
Tilly, D.; Chevallier, F.; Mongin, F. Synthesis 2016, 48, 184-199.
6. Deprotonative Metalation Using Alkali Metal-Non Alkali Metal Combinations.
Chevallier, F. Mongin, F.; Takita, R.; Uchiyama, M. dans Arene Chemistry: Reaction Mechanisms and Methods for Aromatic Compounds, Wiley-VCH, Ed.: Mortier, J. 2016, Chap. 27, 777-812.

Publications: 138

Publications Referenced in HAL :