François-Hugues Porée

UR1 Full Professor

Organization:
Université de Rennes 1 - Faculté de Pharmacie
Address:

2 Avenue du Pr Léon Bernard

Locality:

Rennes 35000

France

Email : francois-hugues [dot] poree [at] univ-rennes1 [dot] fr

Phone : +33 (0) 2 23 23 41 87

Office number : Villejean 05, Office 018

Vitae


2019. Full Professor in Medicinal Chemistry (Institut des Sciences Chimiques de Rennes-UMR 6226, Université de Rennes 1 – Faculté de Pharmacie)

2012. HDR (habilitation). Université Paris Descartes

2005-2019. Assistant Professor (Laboratoire de Pharmacognosie UMR CNRS 8638, Faculté de Pharmacie de Paris - Université Paris Descartes)

2003-2004. Postdoctoral fellow at the Max Planck Institut für Kohlenforschung (Pr Fürstner)

2003. PhD in Organic Chemistry at Université de Cergy-Pontoise (Dr Pancrazi and Pr Ardisson) (Dina Surdin Award from the French Chemical Society)

2001. PhD in Pharmacy. Faculté de Pharmacie de Châtenay-Malabry, Université Paris Sud

2000. Master Degree in Organic Chemistry (Ecole Polytechnique, Palaiseau, France)

1976. Born in Paris (France)

Research Themes

  • Conception of libraries of natural product analogs for SAR studies
  • Total synthesis
  • Medicinal chemistry

keywords: alkaloids, synthesis, cancer 

Publications

Publications

P24. M. Le Roch, D. Afonso, E. Chirkin, X. Guillory, F.-H. Porée.  Structure simplification of the Securinine skeleton reveals the importance of BCD ring system for the cytotoxic activity on HCT116 and HL60 cell lines. Bioorg. Med. Chem. 2022, 58, 116658 (FI 3,641)

P23. A. Keita, J.-F. Franetich, M. Carraz, L. Valentin, M. Bordessoulles, L. Baron, P. Bigeard, F. Dupuy, V. Geay, M. Tefit, V. Sarrasin, S. Michel, C. Lavazec, S. Houzé, D. Mazier, V. Soulard, F.-H. Porée, R. Duval. Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids. Pharmaceutics 2022, 14, 372-doi.org/10.3390/pharmaceutics14020372 (FI 6,321) co-auteur

P22. L. Shen, T. Gaslonde, C. Roullier, H. Wang, J. Bodin, F.-H. Porée, G. Ruprich-Robert, F. Chapeland-Leclerc. Functional characterization of the GATA-type transcription factor PaNsdD in the filamentous fungus Podospora anserina and its interplay with the sterigmatocystin pathway. Appl. Environ. Microbiol. 2022, doi.10.1128/aem.02378-21 (FI 4,792)

P21. S. Bouarfa, P. Jéhan, W. Erb, O. Mongin, F.-H. Porée, T. Roisnel, G. Bentabed-Ababsa, N. Le Yondre, F. Mongin. Aza-aromatic polycycles based on triphenylene and acridine or acridone: synthesis and properties. New J. Chem., 2021, 45, 14414 (FI 3,591)

P20. L. Shen, F.-H. Porée, T. Gaslonde, H. Lalucque, F. Chapeland-Leclerc, G. Ruprich-Robert. Functional characterization of the sterigmatocystin secondary metabolite gene cluster in the filamentous fungus Podospora anserina: involvement in oxidative stress response, sexual development, pigmentation and interspecific competitions Environmental Microbiology, 2019, DOI 10.1111/1462-2920.14698 (FI 5,147)

P19. E. Chirkin, C. Bouzidi, F.-H. Porée. Tungsten-Promoted Hetero-Pauson–Khand Cycloaddition: Application to the Total Synthesis of (–)-Allosecurinine. Synthesis 2019, 51, 2001-2006 (FI 2,650)

P18. P. Menelle, K. Cottet, Y. Fromentin, T. Gaslonde, F.-H. Porée, D. Buisson, M.-C. Lallemand. Progress on PPAPs cyclization: Guttiferone A as a case study. Tetrahedron Lett. 2017, 58, 4876-4879 (FI 2,193)

P17. F. Chapeland-Leclerc, A. Dilmaghani, L. Ez-Zaki, S. Boisnard, B. Da Silva, T. Gaslonde, F.-H. Porée, G. Ruprich-Robert. Systematic gene deletion and functional characterization of histidine kinase phosphorelay receptors (HKRs) in the human pathogenic fungus Aspergillus fumigatus. Fungal Genetics Biol., 2015, 84, 1-11 (FI 3,072)

P16. E. Chirkin, S. Michel, F.-H. Porée. Viability of a [2 + 2 + 1] Hetero-Pauson−Khand Cycloaddition Strategy toward Securinega Alkaloids: Synthesis of the BCD-Ring Core of Securinine and Related Alkaloids. J. Org. Chem. 2015, 80, 6525-6528 (FI 4,849)

P15. E. Chirkin, W. Atkatlian,Q. Do, T. Gaslonde, T.-H. Dufat, S. Michel, P. Lemoine, G. Genta-Jouve, F.-H. Porée. Chiroptical study and absolute configuration of securinine oxidation products. Nat. Prod. Res. 2015, 29, 1235-1242 (FI 1.828)

P14. M. Fomani, E. N. Happi, Kouam, F.-H Porée, M.-C. Lallemand, A. F. K. Waffo, J. D. Wansi. A prenylated acridone alkaloid and ferulate xanthone from barks of Citrus medica (Rutaceae). Z. Naturforsch. B, 2015, 70, 71-75

P13. X. Cachet, F.-H. Porée, S. Michel, P. Lemoine. Tetrahydroalstonine. Acta. Cryst. 2013, E69, o1389-1390

P12. L. Donati, P. Leproux, E. Prost, S. Michel, F. Tillequin, V. Gandon, F.-H. Porée. Solvent/Base Effects in the Selective Domino Synthesis of Phenanthridinones That Involves High-Valent Palladium Species: Experimental and Theoretical Studies. Chem. Eur. J. 2011, 17, 12809-12819 (FI 5,317)

P11. C. Genès, G. Lenglet, S. Depauw, R. Nhili, S. Prado, M.-H. David-Cordonnier, S. Michel, F. Tillequin, F.-H. Porée. Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c] phenanthrolinones as antiproliferative agents. Eur. J. Med. Chem. 2011, 46, 2117-2131 (FI 4,519)

P10. L. Donati, S. Michel, F. Tillequin, F.-H. Porée. Selective Unusual Pd-Mediated Biaryl Coupling Reactions: Solvent Effects with Carbonate Bases. Org. Lett. 2010, 12, 156-158 (FI 6,579)

P9. T. Serbetçi, C. Genès, S. Depauw, S. Prado, F.-H. Porée, M.-P. Hildebrand, M.-H. David-Cordonnier, S. Michel, F. Tillequin. Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents. Eur. J. Med. Chem. 2010, 45, 2547-2558 (FI 4,519)

P8. C. Genès, S. Michel, F. Tillequin, F.-H. Porée. Synthesis of N-substituted benzo[c][1,7]- and benzo[c][1,8] phenanthrolin-(5H)-6-ones through a Pd-mediated Suzuki–Miyaura heteroaryl-aryl coupling reaction. Tetrahedron 2009, 65, 10009-10015 (FI 2,651)

P7. Fürstner, L. C. Bouchez, L. Morency, J.-A. Funel, V. Liepnis, F.-H. Porée, R. Gilmour, D. Laurich, F. Beaufils, M. Tamiya. Total Syntheses of Amphidinolides B1, B4, G1, H1 and Structure Revision of Amphidinolide H2. Chem. Eur. J. 2009, 15, 3983-4010 (FI 5,317)

P6. E. de Lemos, F.-H. Porée, A. Bourin, J. Barbion, E. Agouridas, M.-I. Lannou, A. Commerçon, J.-F. Betzer, A. Pancrazi, J. Ardisson. Total Synthesis of Discodermolide: Optimization of the Effective Synthetic Route. Chem. Eur. J. 2008, 14, 11092-11112 (FI 5,317)

P5. E.de Lemos, F.-H. Porée, A. Commerçon, J.-F. Betzer, A. Pancrazi, J. Ardisson. a-Oxygenated Crotyltitanium and Dyotropic Rearrangement in the Total Synthesis of Discodermolide Angew. Chem. Int. Ed. 2007, 46, 1917-1921 (FI 11,994) (Synfacts 2007, 681)

P4. A. Fürstner, L. C. Bouchez, J.-A. Funel, V. Liepnis, F.-H. Porée, R. Gilmour, F. Beaufils, D. Laurich, M. Tamiya. Total Syntheses of Amphidinolide H and G. Angew. Chem. Int. Ed. 2007, 46, 9265-9270 (FI 11,994) (Synfacts 2008, 333)

P3. S. Centonze-Audureau, F.-H. Porée, J.-F. Betzer, J.-D. Brion, A. Pancrazi, J. Ardisson. Preparation of the three C1-C7, C8-C15 and C16-N22 fragments of the Hsp90 inhibitor Herbimycin A. Synlett 2005, 981-985 (FI 2,151)

P2. F.-H. Porée, J. Barbion, S. Dhulut, J.-F. Betzer, A. Pancrazi, J. Ardisson. Palladium-catalysed coupling reactions: (Z)-vinyl (N,N-diisopropyl)carbamate group as an efficient precursor of a (Z)-vinyl triflate function. Synthesis 2004, 3017-3022 (FI 2,650)

P1. F.-H. Porée, A. Clavel, J.-F. Betzer, A. Pancrazi, J. Ardisson. Efficient preparation of (Z)-alkenyl derivatives from (Z)-vinyl (N,N-diisopropyl)carbamate via Ni-catalysed coupling reactions. Tetrahedron Lett. 2003, 44, 7553-7556 (FI 2,193)


Reviews

_E. Chirkin, F.-H. Porée. The Diels-Alder reaction in total synthesis: a review of the state of the art during the period 2009-2014. Curr. Org. Chem. 2016, 20, 2284-2325. (FI 2,075)

_E. Chirkin, W. Atkatlian, F.-H. Porée, The Securinega Alkaloids. In The Alkaloids; Knölker, H.-J., Ed.; 2015; 74, pp 1–120

_D. Markovic, M. Kolympadi, B. Deguin, F.-H. Porée, M. Turks. The isolation and synthesis of neodolastane diterpenoids. Nat. Prod. Rep. 2015, 32, 230-255 (FI 11,014) Cover Picture

_X. Cachet, F.-H. Porée RSC Adv. 2013, 3, 12466-12484 (FI 3,108)

Publications referenced in HAL :